IFI44

Across TCGA patient cohorts, IFI44 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFI44-associated genes across cancer lineages are p62 Lck ligand, eIF4E, and eIF4G. Each is linked with IFI44 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFI44-to-partner and partner-to-IFI44 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by IFI44-low versus IFI44-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFI44→partner) and Y-score (partner→IFI44) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.461	+2.662	<.001	<.001	3	2
UCEC	eIF4E →	+0.216	+2.662	.006	<.001	3	1
UCEC	eIF4G →	+0.231	+1.415	.047	.046	3	1
UCEC	ERK2 →	+0.167	+2.459	.020	.018	3	1
UCEC	FoxM1 →	+0.244	+1.765	.012	.014	3	1
UCEC	INPP4B →	-0.257	-2.584	.034	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

p62 Lck ligand by IFI44 expression — UCEC

Explore this box plot interactively →