IFI44

Across TCGA cell cohorts, IFI44 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,051 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible IFI44-associated GO terms across cancer lineages are Activation of innate immune response, Defense response to virus, and Antiviral innate immune response. Each is linked with IFI44 in more than 16 cancer types. Because this analysis shows association rather than direction, both IFI44-to-partner and partner-to-IFI44 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Activation of innate immune response grouped by IFI44-low versus IFI44-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFI44→partner) and Y-score (partner→IFI44) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Activation of innate immune response →	+0.070	+1.976	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Defense response to virus →	+0.097	+3.605	<.001	<.001	3	17
KIDNEY	Antiviral innate immune response →	+0.107	+2.578	.002	.004	3	16
STOMACH	Negative regulation of viral genome replication →	+0.217	+3.554	<.001	<.001	3	16
BREAST	Negative regulation of innate immune response →	+0.121	+3.214	<.001	<.001	3	16
SOFT_TISSUE	Positive regulation of canonical NF-kappaB signal transduction →	+0.061	+3.315	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,051 associations by consensus.

Activation of innate immune response by IFI44 expression — SKIN

Explore this box plot interactively →