IER5

Across TCGA cell cohorts, IER5 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IER5-associated genes across cancer lineages are OR6X1, AQP12A, and PRAMEF9. Each is linked with IER5 in more than 1 cancer types. Because this analysis shows association rather than direction, both IER5-to-partner and partner-to-IER5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6X1 grouped by IER5-low versus IER5-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IER5→partner) and Y-score (partner→IER5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR6X1 →	+0.023	+5.285	<.001	.003	3	1
BLOOD_Leukemia	AQP12A →	+0.142	+4.269	<.001	.002	3	1
BLOOD_Leukemia	PRAMEF9 →	+0.003	+4.384	<.001	.006	3	1
BLOOD_Leukemia	GSG1L2 →	+0.034	+4.384	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR8D4 →	+0.006	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	DUSP21 →	+0.022	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR6X1 by IER5 expression — STOMACH

Explore this box plot interactively →