ICOSLG

Across TCGA patient cohorts, ICOSLG RNA expression is significantly associated with the go_rna of many other GO terms, with 6,929 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible ICOSLG-associated GO terms across cancer lineages are Regulation of production of molecular mediator of immune response, CD4-positive, alpha-beta T cell activation, and Negative regulation of cell activation. Each is linked with ICOSLG in more than 17 cancer types. Because this analysis shows association rather than direction, both ICOSLG-to-partner and partner-to-ICOSLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of production of molecular mediator of immune response grouped by ICOSLG-low versus ICOSLG-high in SARC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ICOSLG→partner) and Y-score (partner→ICOSLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	Regulation of production of molecular mediator of immune response →	+0.032	+0.427	<.001	<.001	3	17
LAML	CD4-positive, alpha-beta T cell activation →	+0.036	+0.491	<.001	<.001	3	17
SARC	Negative regulation of cell activation →	+0.031	+0.320	<.001	<.001	3	17
SCLC	Regulation of small GTPase mediated signal transduction →	+0.044	+0.723	<.001	<.001	3	17
STAD	Peptidyl-tyrosine modification →	+0.028	+0.236	.004	.001	2	17
SCLC	Negative regulation of cell-cell adhesion →	+0.082	+0.703	.001	.006	1	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,929 associations by consensus.

Regulation of production of molecular mediator of immune response by ICOSLG expression — SARC

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