ICOSLG

Across TCGA pan-cancer cohorts, ICOSLG RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated ICOSLG data layer compared with 1 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher ICOSLG RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ICOSLG expression acts as an unfavorable survival marker, although some lineages such as SCLC and CESC show a favorable association.

MESO, LGG, and UVM are the cancer types where ICOSLG RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Quartile	III,IV	0.417	0.747	.005	46	view →
LGG	DFS	Median	All	0.664	0.801	<.001	45	view →
UVM	OS	Quartile	All	0.329	0.766	.001	38	view →
SCLC	OS	Tertile	All	0.796	0.426	<.001	33	view →
CESC	OS	Quartile	All	0.846	0.650	.002	28	view →
OV	OS	Median	All	0.267	0.361	.011	28	view →
SKCM	DFS	Median	IV	0.763	0.187	.006	14	view →
LIHC	DFS	Median	All	0.479	0.624	.005	12	view →
BRCA	OS	Tertile	All	0.950	0.969	.015	11	view →
THYM	DFS	Quartile	All	0.779	0.973	.003	11	view →
SARC	OS	Quartile	All	0.448	0.749	.012	9	view →
BLCA	OS	Quartile	III,IV	0.782	0.650	.022	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

ICOSLG–MESO (OS)

Open the MESO breakdown →