ICOSLG

Across TCGA pan-cancer cohorts, ICOSLG RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of ICOSLG’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where ICOSLG RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ICOSLG is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

LIHC, KICH, and KIRP are the cancer types where ICOSLG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ICOSLG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	All	+0.210	.001	6	view →
KICH	Female	All	−0.412	.009	4	view →
KIRP	All	All	−0.272	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

ICOSLG–LIHC

Open the LIHC breakdown →