ICOSLG

Across TCGA patient cohorts, ICOSLG mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ICOSLG-associated genes across cancer lineages are RNU6-508P, RNU6-1292P, and RNU6-649P. Each is linked with ICOSLG in more than 1 cancer types. Because this analysis shows association rather than direction, both ICOSLG-to-partner and partner-to-ICOSLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-508P grouped by ICOSLG-low versus ICOSLG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICOSLG→partner) and Y-score (partner→ICOSLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-508P →	+0.985	+6.453	<.001	.001	3	1
UCEC	RNU6-1292P →	+1.112	+6.453	<.001	.001	3	1
UCEC	RNU6-649P →	+0.720	+5.242	<.001	.007	3	1
UCEC	LINC02819 →	+0.234	+5.081	<.001	.008	3	1
UCEC	MTND6P15 →	+0.299	+5.242	<.001	.007	3	1
UCEC	MTND4P10 →	+0.157	+5.186	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

RNU6-508P by ICOSLG expression — UCEC

Explore this box plot interactively →