ICOSLG

Across TCGA cell cohorts, ICOSLG RNA expression is significantly associated with the go_rna of many other GO terms, with 4,520 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ICOSLG-associated GO terms across cancer lineages are Nuclear-transcribed mRNA poly(A) tail shortening, Positive regulation of amyloid precursor protein catabolic process, and Response to starvation. Each is linked with ICOSLG in more than 10 cancer types. Because this analysis shows association rather than direction, both ICOSLG-to-partner and partner-to-ICOSLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear-transcribed mRNA poly(A) tail shortening grouped by ICOSLG-low versus ICOSLG-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ICOSLG→partner) and Y-score (partner→ICOSLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Nuclear-transcribed mRNA poly(A) tail shortening →	+0.125	+1.167	<.001	<.001	2	11
LARGE_INTESTINE	Positive regulation of amyloid precursor protein catabolic process →	+0.096	+0.845	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Response to starvation →	+0.054	+1.171	<.001	<.001	3	7
URINARY_TRACT	Actin polymerization-dependent cell motility →	+0.130	+1.063	.001	.002	3	7
OVARY	Phospholipid biosynthetic process →	+0.046	+1.409	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Cellular response to starvation →	+0.054	+1.107	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,520 associations by consensus.

Nuclear-transcribed mRNA poly(A) tail shortening by ICOSLG expression — OVARY

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