Q-omics provides the consensus-scored IATPR profile across patient tissues and cancer cell-line models. IATPR expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in SKCM. Among the 18 cancer types available for tumor–normal comparison, IATPR is differentially expressed in 7, with the highest sampling consensus in LUSC. Additionally, IATPR RNA expression shows 8,589 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight SKCM, LUSC, and LSCC as cancer lineages where IATPR shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for IATPR — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes IATPR survival associations across molecular data types. IATPR RNA expression shows survival associations in the most cancer types (20). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible IATPR RNA expression–survival associations across cancer types. High IATPR expression shows unfavorable associations in ACC and UCEC, but favorable associations in SKCM, OV, BLCA and HNSC. The SKCM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify SKCM as the clearest survival context for IATPR RNA expression.
This table summarizes IATPR tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for IATPR. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. IATPR shows lower tumor expression in LUSC and higher tumor expression in BRCA, STAD, CHOL, KIRC and LIHC. The LUSC box plot shows higher IATPR RNA expression in normal versus tumor tissue (log2 FC = −0.234, t-test p < 0.001).
This table shows molecular features associated with IATPR in patient tissues and cancer cell lines. In patient samples, IATPR shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set.
