IATPR

Across TCGA pan-cancer cohorts, IATPR RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of IATPR’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where IATPR RNA is repressed in tumor relative to normal tissue. In most cancer types IATPR is over-expressed in tumor, although a few such as LUSC and BLCA show the opposite, repressed pattern.

LUSC, BRCA, and STAD are the cancer types where IATPR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IATPR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	−0.234	<.001	5	view →
BRCA	Female	All	+0.132	.001	4	view →
STAD	All	All	+0.075	.020	4	view →
CHOL	Female	All	+1.333	.002	3	view →
KIRC	Male	All	+0.152	<.001	3	view →
LIHC	Female	II,III,IV	+0.076	.030	2	view →
BLCA	Male	IV	+0.217	.022	1	view →
BLCA	Female	III,IV	−0.190	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 7 lineages.

IATPR–LUSC

Open the LUSC breakdown →