HYPK

Across TCGA patient cohorts, HYPK mutation is significantly associated with the RNA expression of many other genes, with 313 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HYPK-associated genes across cancer lineages are RNA5SP423, RNA5SP419, and RNA5SP410. Each is linked with HYPK in more than 2 cancer types. Because this analysis shows association rather than direction, both HYPK-to-partner and partner-to-HYPK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP423 grouped by HYPK-low versus HYPK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYPK→partner) and Y-score (partner→HYPK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP423 →	+0.888	+2.454	<.001	.008	3	3
UCEC	RNA5SP419 →	+0.914	+2.813	<.001	.003	3	2
UCEC	RNA5SP410 →	+0.668	+3.052	.001	<.001	3	2
UCEC	RNA5SP417 →	+0.836	+3.088	<.001	.001	3	2
BRCA	OR4M2 →	+0.044	+8.055	<.001	.007	3	1
OV	RNU6-456P →	+0.449	+6.036	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 313 associations by consensus.

RNA5SP423 by HYPK expression — UCEC

Explore this box plot interactively →