HYPK

Across TCGA pan-cancer cohorts, HYPK RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of HYPK’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where HYPK RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HYPK is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

LIHC, KIRC, and BLCA are the cancer types where HYPK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HYPK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+0.275	<.001	9	view →
KIRC	All	All	+0.157	<.001	7	view →
BLCA	All	All	+0.320	.018	6	view →
THCA	All	II,III,IV	−0.311	<.001	6	view →
BRCA	Female	All	−0.218	<.001	6	view →
CHOL	All	All	+1.046	<.001	5	view →
STAD	All	IV	+0.229	.005	5	view →
COAD	All	II,III,IV	+0.212	.002	5	view →
READ	All	All	+0.333	.031	2	view →
PRAD	All	All	+0.270	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

HYPK–LIHC

Open the LIHC breakdown →