HUWE1

Across TCGA patient cohorts, HUWE1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,587 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HUWE1-associated genes across cancer lineages are JADE3, FANCB, and SPIN3. Each is linked with HUWE1 in more than 6 cancer types. Because this analysis shows association rather than direction, both HUWE1-to-partner and partner-to-HUWE1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HUWE1 versus JADE3 in GBM, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HUWE1→partner) and Y-score (partner→HUWE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	JADE3 →	+0.866	+0.243	<.001	<.001	3	7
LSCC	FANCB →	+0.812	+0.213	<.001	<.001	3	7
COAD	SPIN3 →	+0.787	+0.239	<.001	<.001	3	7
HNSC	FAM199X →	+0.530	+0.144	.003	.007	3	7
COAD	KRBOX4 →	+0.552	+0.319	<.001	<.001	3	6
BRCA	FLI1 →	-0.617	-0.224	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,587 associations by consensus.

HUWE1 vs JADE3 — GBM

Explore this scatter interactively →