HUWE1

Across TCGA pan-cancer cohorts, HUWE1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated HUWE1 data layer compared with 11 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher HUWE1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HUWE1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and KIRC show a favorable association.

MESO, SCLC, and KIRC are the cancer types where HUWE1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.432	0.648	<.001	102	view →
SCLC	OS	Quartile	All	0.858	0.543	<.001	71	view →
KIRC	OS	Tertile	All	0.767	0.563	<.001	66	view →
LIHC	DFS	Tertile	All	0.461	0.643	<.001	31	view →
ACC	DFS	Tertile	All	0.372	0.740	.006	28	view →
LUSC	DFS	Median	III,IV	0.523	0.916	.009	23	view →
PAAD	OS	Quartile	All	0.526	0.800	.008	21	view →
LUAD	DFS	Tertile	All	0.736	0.830	.011	17	view →
THCA	OS	Median	II,III,IV	0.851	0.979	.011	14	view →
GBM	DFS	Tertile	All	0.433	0.199	.007	12	view →
BLCA	DFS	Quartile	All	0.196	0.554	.006	11	view →
KIRP	OS	Median	II,III,IV	0.527	0.926	.011	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

HUWE1–MESO (OS)

Open the MESO breakdown →