HUWE1

Across TCGA patient cohorts, HUWE1 protein abundance is significantly associated with the protein abundance of many other proteins, with 18,411 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HUWE1-associated proteins across cancer lineages are HUWE1_S1395, ZFR, and HUWE1_S1907. Each is linked with HUWE1 in more than 9 cancer types. Because this analysis shows association rather than direction, both HUWE1-to-partner and partner-to-HUWE1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HUWE1 versus HUWE1_S1395 in OV, with a Pearson correlation of 0.43.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HUWE1→partner) and Y-score (partner→HUWE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HUWE1_S1395 →	+0.702	+0.262	<.001	<.001	3	10
HNSC	ZFR →	+0.244	+0.243	<.001	<.001	3	9
LSCC	HUWE1_S1907 →	+0.544	+0.312	<.001	<.001	3	9
LSCC	XPO1 →	+0.252	+0.194	<.001	<.001	3	8
BRCA	NUP205 →	+0.204	+0.178	<.001	<.001	3	8
LSCC	NUP93 →	+0.175	+0.174	<.001	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,411 associations by consensus.

HUWE1 vs HUWE1_S1395 — OV

Explore this scatter interactively →