Across TCGA patient cohorts, HTT protein abundance is significantly associated with the RNA expression of many other genes, with 9,669 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HTT-associated genes across cancer lineages are TAPT1, LCORL, and SEPSECS. Each is linked with HTT in more than 6 cancer types. Because this analysis shows association rather than direction, both HTT-to-partner and partner-to-HTT results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTT→partner) and Y-score (partner→HTT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TAPT1 →	+0.644	+0.260	<.001	<.001	3	7
BRCA	LCORL →	+0.485	+0.217	<.001	.001	3	7
OV	SEPSECS →	+0.540	+0.260	.001	.002	3	6
OV	MRFAP1L1 →	+0.825	+0.398	<.001	<.001	3	6
OV	MRFAP1 →	+0.618	+0.283	<.001	<.001	3	6
OV	HAUS3 →	+0.712	+0.365	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,669 associations by consensus.

Exploration

HTT survival (RNA) · tumor vs normal (RNA) · all HTT data types