HTR7

Across TCGA cell cohorts, HTR7 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible HTR7-associated genes across cancer lineages are OR2T35, FAM24A, and OR8B12. Each is linked with HTR7 in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR7-to-partner and partner-to-HTR7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T35 grouped by HTR7-low versus HTR7-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR7→partner) and Y-score (partner→HTR7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OR2T35 →	+0.020	+5.614	<.001	.002	3	1
PANCREAS	FAM24A →	+0.083	+5.614	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR8B12 →	+0.037	+2.827	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR10D3 →	+0.054	+2.637	<.001	.007	3	1
LUNG_NSCLC_LUAD	CLPSL1 →	+0.253	+3.252	<.001	<.001	3	1
LUNG_NSCLC_LUAD	C5orf58 →	+1.428	+2.718	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

OR2T35 by HTR7 expression — PANCREAS

Explore this box plot interactively →