HTR7

Across TCGA pan-cancer cohorts, HTR7 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of HTR7’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HTR7 RNA is repressed in tumor relative to normal tissue. In most cancer types HTR7 is over-expressed in tumor, although a few such as COAD and STAD show the opposite, repressed pattern.

COAD, HNSC, and KIRC are the cancer types where HTR7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HTR7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.080	<.001	12	view →
HNSC	Female	IV	+3.966	<.001	11	view →
KIRC	Male	All	+0.813	<.001	11	view →
LUSC	All	II,III,IV	+1.654	<.001	6	view →
STAD	All	II,III,IV	−0.585	<.001	6	view →
READ	Female	All	−0.944	.001	2	view →
BLCA	Female	All	−0.831	.030	2	view →
KIRP	All	All	+0.380	.002	2	view →
PRAD	All	All	−0.182	.031	2	view →
UCEC	All	All	−0.173	.009	2	view →
BRCA	All	All	−0.151	.025	2	view →
BLCA	Male	III,IV	+1.804	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

HTR7–COAD

Open the COAD breakdown →