Q-omics provides the consensus-scored HTR5BP profile across patient tissues and cancer cell-line models. HTR5BP expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in KICH. Among the 18 cancer types available for tumor–normal comparison, HTR5BP is differentially expressed in 7, with the highest sampling consensus in BLCA. Additionally, HTR5BP RNA expression shows 16,160 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight KICH, BLCA, and THYM as cancer lineages where HTR5BP shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HTR5BP — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HTR5BP survival associations across molecular data types. HTR5BP RNA expression shows survival associations in the most cancer types (21). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HTR5BP RNA expression–survival associations across cancer types. High HTR5BP expression shows unfavorable associations in KICH, LGG, ACC, LIHC and KIRC, but favorable associations in LUAD. The KICH Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify KICH as the clearest survival context for HTR5BP RNA expression.
This table summarizes HTR5BP tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7. The strongest signals are observed in BLCA for RNA.
This table ranks reproducible tumor–normal expression differences for HTR5BP. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HTR5BP shows lower tumor expression in THCA and higher tumor expression in BLCA, HNSC, KIRC, CHOL and READ. The BLCA box plot shows higher HTR5BP RNA expression in tumor versus normal tissue (log2 FC = +0.142, t-test p = .009).
This table shows molecular features associated with HTR5BP in patient tissues and cancer cell lines. In patient samples, HTR5BP shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
