HTR5BP

Across TCGA pan-cancer cohorts, HTR5BP RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated HTR5BP data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher HTR5BP RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HTR5BP expression acts as an unfavorable survival marker, although some lineages such as LUAD and BRCA show a favorable association.

KICH, LUAD, and LGG are the cancer types where HTR5BP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	III,IV	0.194	0.863	.001	73	view →
LUAD	OS	Tertile	All	0.544	0.247	.002	71	view →
LGG	OS	Quartile	All	0.380	0.608	<.001	38	view →
ACC	DFS	Tertile	All	0.356	0.674	.003	37	view →
LIHC	DFS	Median	II,III,IV	0.228	0.412	.001	36	view →
KIRC	DFS	Tertile	All	0.547	0.695	.006	35	view →
OV	DFS	Tertile	IV	0.339	0.623	.007	24	view →
BRCA	OS	Tertile	III,IV	0.736	0.408	.009	21	view →
SKCM	OS	Tertile	III,IV	0.873	0.744	.007	16	view →
GBM	DFS	Tertile	All	0.419	0.194	.006	15	view →
COAD	DFS	Tertile	All	0.440	0.619	.007	13	view →
KIRP	DFS	Quartile	IV	0.031	0.524	.017	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

HTR5BP–KICH (OS)

Open the KICH breakdown →