HTR5A

Across TCGA patient cohorts, HTR5A mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTR5A-associated genes across cancer lineages are TFRC, 4E-BP1, and GATA3. Each is linked with HTR5A in more than 2 cancer types. Because this analysis shows association rather than direction, both HTR5A-to-partner and partner-to-HTR5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by HTR5A-low versus HTR5A-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR5A→partner) and Y-score (partner→HTR5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	TFRC →	+0.599	+2.459	.027	.019	3	3
STAD	4E-BP1 →	+0.389	+3.169	.002	.017	3	3
SKCM	GATA3 →	-0.152	-2.442	.021	.017	3	3
STAD	Caspase-7-cleavedD198 →	+1.115	+2.459	<.001	.019	3	2
UCEC	eIF4E →	+0.171	+3.598	.010	.001	3	2
UCEC	ER-alpha →	+0.509	+1.362	.049	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

TFRC by HTR5A expression — STAD

Explore this box plot interactively →