HTR5A

Across TCGA pan-cancer cohorts, HTR5A RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated HTR5A data layer compared with 11 for mutation status.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher HTR5A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HTR5A expression acts as an unfavorable survival marker, although some lineages such as LGG and KIRP show a favorable association.

LIHC, UVM, and KICH are the cancer types where HTR5A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	II,III,IV	0.459	0.749	<.001	57	view →
UVM	OS	Median	III,IV	0.224	0.836	<.001	45	view →
KICH	DFS	Tertile	II,III,IV	0.521	0.950	.006	36	view →
DLBC	OS	Tertile	III,IV	0.154	0.735	.010	28	view →
SKCM	DFS	Tertile	IV	0.042	0.477	.001	27	view →
LGG	DFS	Median	All	0.527	0.364	.007	25	view →
ACC	OS	Tertile	II,III,IV	0.717	0.907	.004	25	view →
KIRP	DFS	Tertile	All	1.000	0.896	.022	24	view →
COAD	OS	Tertile	IV	0.039	0.660	<.001	18	view →
BLCA	DFS	Tertile	II,III,IV	0.576	0.315	.034	18	view →
THYM	OS	Median	II,III,IV	0.959	0.727	.010	11	view →
MESO	DFS	Tertile	III,IV	0.191	0.428	.043	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

HTR5A–LIHC (OS)

Open the LIHC breakdown →