HTR5A

Across TCGA pan-cancer cohorts, HTR5A RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of HTR5A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HTR5A RNA is repressed in tumor relative to normal tissue. In most cancer types HTR5A is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, READ, and THCA are the cancer types where HTR5A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HTR5A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−0.007	.009	4	view →
READ	All	All	−0.026	.019	3	view →
THCA	All	All	−0.008	.011	2	view →
STAD	All	All	−0.041	.020	1	view →
KIRC	All	All	−0.009	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

HTR5A–COAD

Open the COAD breakdown →