HTR5A

Across TCGA cell cohorts, HTR5A RNA expression is significantly associated with the go_rna of many other GO terms, with 503 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HTR5A-associated GO terms across cancer lineages are Negative regulation of coagulation, Response to catecholamine, and DNA damage checkpoint signaling. Each is linked with HTR5A in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR5A-to-partner and partner-to-HTR5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of coagulation grouped by HTR5A-low versus HTR5A-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR5A→partner) and Y-score (partner→HTR5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of coagulation →	-0.120	-0.121	<.001	.005	3	2
LUNG_SCLC	Response to catecholamine →	+0.145	+0.114	<.001	.008	3	2
BLOOD_Leukemia	DNA damage checkpoint signaling →	+0.059	+0.011	<.001	.005	3	2
BLOOD_Leukemia	Negative regulation of cell cycle process →	+0.062	+0.012	<.001	.002	3	2
BLOOD_Leukemia	Negative regulation of hemostasis →	-0.072	-0.015	.003	.008	3	2
BLOOD_Leukemia	Carbohydrate derivative catabolic process →	-0.041	-0.012	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 503 associations by consensus.

Negative regulation of coagulation by HTR5A expression — LUNG_SCLC

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