HTR5A

Across TCGA cell cohorts, HTR5A mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HTR5A-associated genes across cancer lineages are IQCF5, ASB17, and OR1N2. Each is linked with HTR5A in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR5A-to-partner and partner-to-HTR5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by HTR5A-low versus HTR5A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR5A→partner) and Y-score (partner→HTR5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IQCF5 →	+0.021	+3.700	<.001	.009	3	2
OVARY	ASB17 →	+0.014	+4.222	<.001	.006	3	1
OVARY	OR1N2 →	+0.018	+3.700	<.001	.005	3	1
OVARY	FAM170B →	+0.004	+4.222	<.001	.006	3	1
OVARY	HS3ST4 →	+0.055	+3.662	.008	.009	3	1
OVARY	OR2T4 →	+0.020	+4.222	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

IQCF5 by HTR5A expression — LARGE_INTESTINE

Explore this box plot interactively →