HTR5A

Across TCGA cell cohorts, HTR5A mutation is significantly associated with the mutation status of many other genes, with 978 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HTR5A-associated genes across cancer lineages are ADAMTS4, TRIM41, and IQGAP3. Each is linked with HTR5A in more than 3 cancer types. Because this analysis shows association rather than direction, both HTR5A-to-partner and partner-to-HTR5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAMTS4 grouped by HTR5A-low versus HTR5A-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR5A→partner) and Y-score (partner→HTR5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ADAMTS4 →	+5.392	+5.392	.004	.004	1	4
BLOOD_Leukemia	TRIM41 →	+4.894	+4.894	.004	.004	1	4
OVARY	IQGAP3 →	+4.632	+5.345	<.001	<.001	1	3
BLOOD_Leukemia	TMEM185B →	+4.894	+5.870	<.001	<.001	1	3
BLOOD_Leukemia	PCDHGB6 →	+4.157	+5.430	<.001	<.001	1	3
BLOOD_Leukemia	PCDHB7 →	+3.157	+4.665	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 978 associations by consensus.

ADAMTS4 by HTR5A expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →