HTR4

Across TCGA cell cohorts, HTR4 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HTR4-associated genes across cancer lineages are SCN10A, OR6C75, and USP17L22. Each is linked with HTR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR4-to-partner and partner-to-HTR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCN10A grouped by HTR4-low versus HTR4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR4→partner) and Y-score (partner→HTR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SCN10A →	+0.004	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR6C75 →	+0.022	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	USP17L22 →	+0.029	+4.947	<.001	.001	3	1
SKIN	ANKRD40CL →	+0.044	+3.793	.003	.007	3	1
SKIN	GPR152 →	+0.055	+4.347	<.001	.001	3	1
SKIN	C4orf50 →	+0.025	+5.099	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

SCN10A by HTR4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →