HTR3B

Across TCGA patient cohorts, HTR3B mutation is significantly associated with the RNA expression of many other genes, with 1,818 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTR3B-associated genes across cancer lineages are CDCA5, CDKN3, and MND1. Each is linked with HTR3B in more than 3 cancer types. Because this analysis shows association rather than direction, both HTR3B-to-partner and partner-to-HTR3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDCA5 grouped by HTR3B-low versus HTR3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR3B→partner) and Y-score (partner→HTR3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDCA5 →	+0.837	+3.180	.001	<.001	3	4
UCEC	CDKN3 →	+0.775	+3.708	.001	<.001	3	3
UCEC	MND1 →	+0.667	+2.502	.006	.002	3	3
SKCM	SNRPF →	+0.379	+3.484	.001	.002	3	3
UCEC	RFC4 →	+0.595	+4.247	.006	<.001	3	3
UCEC	RAD54L →	+0.687	+3.716	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,818 associations by consensus.

CDCA5 by HTR3B expression — UCEC

Explore this box plot interactively →