HTR2C

Across TCGA patient cohorts, HTR2C mutation is significantly associated with the RNA expression of many other genes, with 4,403 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTR2C-associated genes across cancer lineages are TMEM62, RNU6-709P, and RN7SKP49. Each is linked with HTR2C in more than 3 cancer types. Because this analysis shows association rather than direction, both HTR2C-to-partner and partner-to-HTR2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM62 grouped by HTR2C-low versus HTR2C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR2C→partner) and Y-score (partner→HTR2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMEM62 →	+0.500	+1.584	<.001	<.001	3	3
CESC	RNU6-709P →	+0.135	+5.174	<.001	.001	3	3
GBM	RN7SKP49 →	+0.212	+5.149	<.001	.007	3	3
LUSC	DDX19B →	+0.357	+2.426	.003	.002	3	3
UCEC	SLBP →	+0.470	+1.461	<.001	<.001	3	3
UCEC	SCNN1G →	-1.352	-1.450	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,403 associations by consensus.

TMEM62 by HTR2C expression — UCEC

Explore this box plot interactively →