HTR2C

Across TCGA pan-cancer cohorts, HTR2C RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of HTR2C’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HTR2C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HTR2C is over-expressed in tumor.

HNSC, BLCA, and LUSC are the cancer types where HTR2C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HTR2C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.839	<.001	11	view →
BLCA	All	All	+0.851	.002	8	view →
LUSC	Female	All	+1.165	<.001	6	view →
STAD	All	All	+0.216	.021	2	view →
LUAD	All	All	+0.292	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

HTR2C–HNSC

Open the HNSC breakdown →