HTR2C

Across TCGA pan-cancer cohorts, HTR2C RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated HTR2C data layer compared with 14 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher HTR2C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HTR2C expression acts as an unfavorable survival marker, although some lineages such as LGG and ESCA show a favorable association.

KIRC, READ, and ACC are the cancer types where HTR2C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.536	0.668	<.001	182	view →
READ	DFS	Tertile	III,IV	0.366	0.857	<.001	100	view →
ACC	OS	Quartile	All	0.536	0.872	<.001	90	view →
HNSC	OS	Tertile	All	0.594	0.745	<.001	63	view →
LGG	DFS	Median	All	0.815	0.654	<.001	43	view →
STAD	DFS	Quartile	All	0.434	0.590	.007	34	view →
THCA	OS	Tertile	All	0.946	0.988	.002	33	view →
LIHC	DFS	Quartile	All	0.302	0.473	.001	25	view →
UVM	DFS	Tertile	All	0.213	0.761	.017	18	view →
MESO	OS	Tertile	IV	0.292	0.638	.046	9	view →
BRCA	OS	Tertile	All	0.901	0.935	.022	8	view →
ESCA	OS	Tertile	II,III,IV	0.696	0.397	.017	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

HTR2C–KIRC (DFS)

Open the KIRC breakdown →