HTR2C

Across TCGA cell cohorts, HTR2C mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HTR2C-associated genes across cancer lineages are DPRX, TMEM95, and MYL2. Each is linked with HTR2C in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR2C-to-partner and partner-to-HTR2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPRX grouped by HTR2C-low versus HTR2C-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR2C→partner) and Y-score (partner→HTR2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DPRX →	+0.328	+5.228	<.001	.005	3	2
LARGE_INTESTINE	TMEM95 →	+0.014	+3.700	<.001	.009	3	1
LUNG_SCLC	MYL2 →	+0.256	+4.269	<.001	.005	3	1
LUNG_SCLC	NEU2 →	+0.015	+4.643	<.001	.004	3	1
LUNG_SCLC	LCE3D →	+0.078	+4.817	<.001	.001	3	1
LUNG_SCLC	ACER1 →	+0.066	+4.044	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

DPRX by HTR2C expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →