HTR1E

Across TCGA patient cohorts, HTR1E mutation is significantly associated with the RNA expression of many other genes, with 1,663 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTR1E-associated genes across cancer lineages are TAF9, CRYBB2P1, and CINP. Each is linked with HTR1E in more than 2 cancer types. Because this analysis shows association rather than direction, both HTR1E-to-partner and partner-to-HTR1E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAF9 grouped by HTR1E-low versus HTR1E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR1E→partner) and Y-score (partner→HTR1E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TAF9 →	+0.512	+3.928	<.001	<.001	3	3
UCEC	CRYBB2P1 →	+0.408	+2.021	.004	.001	3	3
UCEC	CINP →	+0.235	+2.053	.008	.001	3	3
UCEC	CMC2 →	+0.374	+1.830	.001	.007	3	3
UCEC	SRSF4 →	+0.353	+2.471	.002	.001	3	3
UCEC	ACYP1 →	+0.388	+2.764	.007	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,663 associations by consensus.

TAF9 by HTR1E expression — UCEC

Explore this box plot interactively →