HTR1E

Across TCGA pan-cancer cohorts, HTR1E RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of HTR1E’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where HTR1E RNA is repressed in tumor relative to normal tissue. In most cancer types HTR1E is over-expressed in tumor, although a few such as THCA and STAD show the opposite, repressed pattern.

THCA, STAD, and BRCA are the cancer types where HTR1E tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HTR1E RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−1.335	<.001	10	view →
STAD	All	All	−0.409	.002	7	view →
BRCA	Female	II,III,IV	+0.224	<.001	4	view →
KIRC	All	II,III,IV	−0.012	.005	4	view →
UCEC	All	All	−0.773	.014	2	view →
PRAD	All	All	−0.290	<.001	2	view →
COAD	All	All	−0.030	.026	2	view →
ESCA	All	All	−1.191	.020	1	view →
LUAD	Female	All	+0.055	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

HTR1E–THCA

Open the THCA breakdown →