HTR1E

Across TCGA pan-cancer cohorts, HTR1E RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated HTR1E data layer compared with 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HTR1E RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HTR1E expression acts as an unfavorable survival marker, although some lineages such as KICH and LGG show a favorable association.

UCEC, CHOL, and KICH are the cancer types where HTR1E RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.598	0.735	.002	90	view →
CHOL	OS	Tertile	II,III,IV	0.019	0.675	<.001	36	view →
KICH	OS	Median	III,IV	1.000	0.766	.006	21	view →
ACC	DFS	Median	All	0.316	0.588	.011	12	view →
HNSC	OS	Tertile	All	0.572	0.709	.010	12	view →
LGG	DFS	Quartile	All	0.898	0.757	.003	12	view →
LIHC	DFS	Tertile	III,IV	0.131	0.349	.022	9	view →
KIRP	OS	Tertile	II,III,IV	0.570	0.875	.018	9	view →
THCA	DFS	Tertile	All	0.983	0.914	.017	6	view →
SKCM	OS	Tertile	II,III,IV	1.000	0.822	.030	6	view →
STAD	DFS	Median	III,IV	0.523	0.230	.044	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

HTR1E–UCEC (OS)

Open the UCEC breakdown →