HTR1E

Across TCGA patient cohorts, HTR1E mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTR1E-associated genes across cancer lineages are PI3K-p85, ACC_pS79, and FASN. Each is linked with HTR1E in more than 2 cancer types. Because this analysis shows association rather than direction, both HTR1E-to-partner and partner-to-HTR1E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PI3K-p85 grouped by HTR1E-low versus HTR1E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR1E→partner) and Y-score (partner→HTR1E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PI3K-p85 →	-0.241	-1.874	.002	.049	3	3
LUSC	ACC_pS79 →	+0.438	+2.821	.022	.035	3	2
COAD	FASN →	+0.727	+2.815	<.001	.036	3	2
UCEC	Notch1 →	+0.172	+2.013	.001	.016	3	2
UCEC	ATM →	-0.397	-2.321	.022	.034	3	2
UCEC	Caspase-7-cleavedD198 →	+0.615	+2.019	.006	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

PI3K-p85 by HTR1E expression — UCEC

Explore this box plot interactively →