HTR1E

Across TCGA cell cohorts, HTR1E RNA expression is significantly associated with the mutation status of many other genes, with 138 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HTR1E-associated genes across cancer lineages are LPA, ZADH2, and THSD7B. Each is linked with HTR1E in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR1E-to-partner and partner-to-HTR1E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LPA grouped by HTR1E-low versus HTR1E-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR1E→partner) and Y-score (partner→HTR1E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	LPA →	+4.357	+0.040	.006	<.001	3	2
LARGE_INTESTINE	ZADH2 →	+3.345	+0.070	.007	<.001	3	2
BREAST	THSD7B →	+2.544	+0.275	.009	.002	3	2
BREAST	CACNA1H →	+3.392	+0.345	<.001	<.001	3	2
LARGE_INTESTINE	C1orf115 →	+4.930	+0.066	.001	<.001	3	2
SOFT_TISSUE	TRPA1 →	+5.369	+0.223	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 138 associations by consensus.

LPA by HTR1E expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →