HTR1E

Across TCGA cell cohorts, HTR1E mutation is significantly associated with the drug of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HTR1E-associated genes across cancer lineages are Niraparib, UNC1215, and PARP_0108. Each is linked with HTR1E in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR1E-to-partner and partner-to-HTR1E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Niraparib grouped by HTR1E-low versus HTR1E-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR1E→partner) and Y-score (partner→HTR1E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Niraparib →	+0.351	+2.646	.049	.047	3	1
LARGE_INTESTINE	UNC1215 →	+0.241	+2.716	.017	.042	3	1
LARGE_INTESTINE	PARP_0108 →	+0.830	+2.649	.008	.046	3	1
LARGE_INTESTINE	Luminespib →	+0.640	+2.646	.035	.047	3	1
LARGE_INTESTINE	Nelarabine →	+0.275	+2.649	.037	.046	2	1
LARGE_INTESTINE	Gallibiscoquinazole →	+0.377	+2.649	.021	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Niraparib by HTR1E expression — LARGE_INTESTINE

Explore this box plot interactively →