HTR1D

Across TCGA patient cohorts, HTR1D mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTR1D-associated genes across cancer lineages are mTOR_pS2448, c-Met_pY1235, and Gab2. Each is linked with HTR1D in more than 2 cancer types. Because this analysis shows association rather than direction, both HTR1D-to-partner and partner-to-HTR1D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by HTR1D-low versus HTR1D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR1D→partner) and Y-score (partner→HTR1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.134	-2.986	.029	.035	3	3
UCEC	c-Met_pY1235 →	+0.077	+1.807	.011	.027	3	3
SKCM	Gab2 →	-0.392	-2.321	.048	.035	3	2
SKCM	PAI-1 →	+0.714	+3.016	.030	.018	3	2
SKCM	Bap1-c-4 →	-0.304	-2.321	.043	.035	3	2
SKCM	DJ-1 →	+0.302	+3.000	<.001	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

mTOR_pS2448 by HTR1D expression — UCEC

Explore this box plot interactively →