HTR1D

Across TCGA pan-cancer cohorts, HTR1D RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of HTR1D’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HTR1D RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HTR1D is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

HNSC, COAD, and THCA are the cancer types where HTR1D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HTR1D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.116	<.001	12	view →
COAD	Male	II,III,IV	+2.814	<.001	11	view →
THCA	Male	III,IV	+0.598	<.001	10	view →
LUAD	Male	II,III,IV	+2.226	<.001	9	view →
STAD	All	II,III,IV	+1.776	<.001	8	view →
LIHC	All	II,III,IV	+1.223	<.001	7	view →
BRCA	All	II,III,IV	+0.910	<.001	6	view →
KICH	All	All	−0.259	.003	5	view →
PAAD	All	All	+1.815	.008	4	view →
UCEC	All	All	+0.391	.023	4	view →
KIRP	All	All	+0.295	.014	4	view →
READ	All	All	+2.112	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

HTR1D–HNSC

Open the HNSC breakdown →