HTR1D

Across TCGA pan-cancer cohorts, HTR1D RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated HTR1D data layer compared with 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HTR1D RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HTR1D expression acts as an unfavorable survival marker, although some lineages such as BRCA and OV show a favorable association.

HNSC, BRCA, and LIHC are the cancer types where HTR1D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.607	0.760	<.001	91	view →
BRCA	DFS	Tertile	III,IV	0.900	0.715	<.001	64	view →
LIHC	OS	Tertile	All	0.678	0.861	<.001	55	view →
ACC	DFS	Tertile	All	0.138	0.593	<.001	48	view →
LGG	OS	Median	All	0.755	0.865	<.001	42	view →
LUAD	DFS	Tertile	All	0.222	0.456	<.001	40	view →
KIRC	DFS	Quartile	All	0.482	0.703	.009	39	view →
PAAD	DFS	Tertile	All	0.192	0.445	<.001	35	view →
LUSC	OS	Quartile	All	0.729	0.828	.006	30	view →
UVM	DFS	Tertile	II,III,IV	0.432	0.799	.004	27	view →
CESC	DFS	Tertile	All	0.641	0.852	<.001	24	view →
ESCA	OS	Median	All	0.647	1.000	.015	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

HTR1D–HNSC (OS)

Open the HNSC breakdown →