HTR1D

Across TCGA cell cohorts, HTR1D RNA expression is significantly associated with the go_rna of many other GO terms, with 3,258 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible HTR1D-associated GO terms across cancer lineages are Intestine smooth muscle contraction, Positive regulation of exosomal secretion, and Cellular response to environmental stimulus. Each is linked with HTR1D in more than 10 cancer types. Because this analysis shows association rather than direction, both HTR1D-to-partner and partner-to-HTR1D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intestine smooth muscle contraction grouped by HTR1D-low versus HTR1D-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR1D→partner) and Y-score (partner→HTR1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Intestine smooth muscle contraction →	+0.894	+2.333	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Positive regulation of exosomal secretion →	+0.111	+1.296	<.001	.002	3	10
SOFT_TISSUE	Cellular response to environmental stimulus →	+0.040	+0.805	<.001	<.001	1	10
LUNG_NSCLC_LUSC	Positive regulation of natural killer cell activation →	+0.278	+1.408	<.001	.003	3	8
BREAST	Positive regulation of chemotaxis →	+0.132	+1.079	<.001	<.001	3	8
LIVER	Negative regulation of immune response →	+0.089	+2.082	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,258 associations by consensus.

Intestine smooth muscle contraction by HTR1D expression — LARGE_INTESTINE

Explore this box plot interactively →