HTR1D

Across TCGA cell cohorts, HTR1D mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible HTR1D-associated genes across cancer lineages are OR2AJ1, TAS2R60, and PATE3. Each is linked with HTR1D in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR1D-to-partner and partner-to-HTR1D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2AJ1 grouped by HTR1D-low versus HTR1D-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR1D→partner) and Y-score (partner→HTR1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR2AJ1 →	+0.042	+4.867	<.001	.009	3	1
OVARY	TAS2R60 →	+0.025	+4.450	.008	.004	3	1
OVARY	PATE3 →	+0.027	+4.228	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR2AJ1 by HTR1D expression — BLOOD_Lymphoma

Explore this box plot interactively →