HTR1B

Across TCGA cell cohorts, HTR1B mutation is significantly associated with the RNA expression of many other genes, with 48 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HTR1B-associated genes across cancer lineages are M1AP, ACTRT1, and WFDC8. Each is linked with HTR1B in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR1B-to-partner and partner-to-HTR1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, M1AP grouped by HTR1B-low versus HTR1B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR1B→partner) and Y-score (partner→HTR1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	M1AP →	+0.561	+3.451	.008	.005	3	2
OESOPHAGUS	ACTRT1 →	+0.023	+4.906	<.001	.006	3	1
OESOPHAGUS	WFDC8 →	+0.020	+4.906	<.001	.006	3	1
OESOPHAGUS	GRIFIN →	+0.080	+4.906	<.001	.006	3	1
BLOOD_Leukemia	TAS2R40 →	+0.088	+3.619	.001	.007	3	1
BLOOD_Leukemia	SMIM32 →	+0.022	+3.847	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

M1AP by HTR1B expression — LARGE_INTESTINE

Explore this box plot interactively →