HTR1B

Across TCGA pan-cancer cohorts, HTR1B RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated HTR1B data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher HTR1B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HTR1B expression acts as an unfavorable survival marker, although some lineages such as LIHC and THYM show a favorable association.

MESO, STAD, and LIHC are the cancer types where HTR1B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.239	0.526	<.001	93	view →
STAD	OS	Quartile	III,IV	0.255	0.594	.007	61	view →
LIHC	OS	Quartile	II,III,IV	0.976	0.677	.002	31	view →
THYM	DFS	Tertile	II,III,IV	1.000	0.783	.006	27	view →
UCS	DFS	Tertile	IV	0.936	0.364	.024	24	view →
KIRP	DFS	Tertile	All	0.521	0.871	<.001	23	view →
LUAD	DFS	Median	III,IV	0.561	0.262	.011	17	view →
SARC	DFS	Median	All	0.463	0.699	.001	17	view →
KIRC	OS	Tertile	All	0.895	0.827	.007	16	view →
READ	OS	Tertile	II,III,IV	0.828	0.413	.006	14	view →
ACC	DFS	Median	All	0.724	0.404	.013	13	view →
HNSC	DFS	Median	IV	0.381	0.256	.016	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

HTR1B–MESO (OS)

Open the MESO breakdown →