HSPH1

Across TCGA patient cohorts, HSPH1 mutation is significantly associated with the RNA expression of many other genes, with 4,058 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSPH1-associated genes across cancer lineages are RN7SKP214, RNA5SP413, and RNVU1-28. Each is linked with HSPH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HSPH1-to-partner and partner-to-HSPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP214 grouped by HSPH1-low versus HSPH1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPH1→partner) and Y-score (partner→HSPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SKP214 →	+0.487	+3.809	.001	.009	3	3
LUSC	RNA5SP413 →	+1.301	+5.081	<.001	.004	3	3
UCEC	RNVU1-28 →	+0.510	+1.220	<.001	.007	3	2
BRCA	MTND2P38 →	+0.029	+4.341	<.001	.009	3	2
CESC	RNA5SP110 →	+0.319	+6.164	<.001	<.001	3	2
CESC	LINC01677 →	+0.028	+5.342	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,058 associations by consensus.

RN7SKP214 by HSPH1 expression — BLCA

Explore this box plot interactively →