HSPB11

Across TCGA patient cohorts, HSPB11 mutation is significantly associated with the RNA expression of many other genes, with 428 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSPB11-associated genes across cancer lineages are SNORD114-15, RNU6-622P, and MIR329-2. Each is linked with HSPB11 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSPB11-to-partner and partner-to-HSPB11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD114-15 grouped by HSPB11-low versus HSPB11-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPB11→partner) and Y-score (partner→HSPB11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SNORD114-15 →	+0.464	+7.924	<.001	.008	3	1
LUSC	RNU6-622P →	+0.350	+7.924	<.001	.008	3	1
LUSC	MIR329-2 →	+0.408	+7.924	<.001	.008	3	1
BLCA	MIR587 →	+0.539	+5.788	.002	.003	3	1
UCEC	FOXRED2 →	+0.838	+3.491	<.001	.002	3	1
UCEC	ITPK1 →	+0.516	+3.201	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 428 associations by consensus.

SNORD114-15 by HSPB11 expression — LUSC

Explore this box plot interactively →