HSPB11

Across TCGA pan-cancer cohorts, HSPB11 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated HSPB11 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher HSPB11 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HSPB11 expression acts as an unfavorable survival marker, although some lineages such as ESCA and CHOL show a favorable association.

ACC, KICH, and LIHC are the cancer types where HSPB11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.471	0.758	<.001	114	view →
KICH	OS	Median	II,III,IV	0.613	1.000	<.001	100	view →
LIHC	DFS	Median	All	0.457	0.625	<.001	86	view →
KIRC	DFS	Median	II,III,IV	0.460	0.635	.006	61	view →
LGG	DFS	Median	All	0.583	0.881	<.001	54	view →
KIRP	DFS	Median	II,III,IV	0.522	0.811	.001	50	view →
SCLC	OS	Tertile	All	0.384	0.734	<.001	49	view →
ESCA	DFS	Median	All	1.000	0.471	.002	33	view →
SARC	DFS	Median	All	0.526	0.692	<.001	25	view →
UCS	DFS	Tertile	IV	0.239	0.942	.024	24	view →
CHOL	DFS	Median	All	0.625	0.221	.013	21	view →
UVM	OS	Median	III,IV	0.281	1.000	.003	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

HSPB11–ACC (OS)

Open the ACC breakdown →