HSPB11

Across TCGA pan-cancer cohorts, HSPB11 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HSPB11’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HSPB11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HSPB11 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, THCA, and HNSC are the cancer types where HSPB11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSPB11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.707	<.001	12	view →
THCA	Male	III,IV	−1.322	<.001	11	view →
HNSC	Male	III,IV	+0.879	<.001	11	view →
LIHC	Male	II,III,IV	+1.172	<.001	9	view →
KICH	Female	II,III,IV	−1.509	<.001	7	view →
BLCA	Female	All	+1.040	.003	6	view →
BRCA	All	III,IV	+0.646	<.001	6	view →
LUAD	Male	All	+0.568	<.001	5	view →
STAD	Female	All	+0.691	.020	4	view →
ESCA	All	All	+0.563	.009	4	view →
LUSC	All	All	+0.494	<.001	4	view →
CHOL	All	All	+1.322	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HSPB11–KIRC

Open the KIRC breakdown →