HSPB11

Across TCGA patient cohorts, HSPB11 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSPB11-associated genes across cancer lineages are mv Endothelial cells, lymphatic Endothelial cells, and Endothelial cells. Each is linked with HSPB11 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSPB11-to-partner and partner-to-HSPB11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mv Endothelial cells grouped by HSPB11-low versus HSPB11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPB11→partner) and Y-score (partner→HSPB11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mv Endothelial cells →	-0.028	-2.311	.019	.036	3	1
UCEC	lymphatic Endothelial cells →	-0.025	-2.959	.038	.036	2	1
UCEC	Endothelial cells →	-0.047	-2.279	.014	.036	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

mv Endothelial cells by HSPB11 expression — UCEC

Explore this box plot interactively →